We are primarily using cryo-EM, combined with NMR, X-ray crystallography, ITC, modeling etc... to determine the structure of large macromolecular nano-machines, particularly in bacteria and viruses.

Specifically, we are interested in the following aspects:

- Bacterial motility and adherence

- Macromolecular transport across the bacterial and viral cell membrane(s)

- The bacterial cytoskeleton, and microcompartments

- Host-pathogen interaction