We are primarily using cryo-EM, combined with NMR, X-ray crystallography, ITC, modeling etc... to determine the structure of large macromolecular nano-machines, particularly in bacteria and viruses.
Specifically, we are interested in the following aspects:
- Bacterial motility and adherence
- Macromolecular transport across the bacterial and viral cell membrane(s)
- The bacterial cytoskeleton, and microcompartments
- Host-pathogen interaction